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Chemical Structure| 501-36-0 Chemical Structure| 501-36-0
Chemical Structure| 501-36-0

Resveratrol

CAS No.: 501-36-0

Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.

Synonyms: trans-Resveratrol; SRT501; Vineatrol 20M

4.5 *For Research Use Only !

Cat. No.: A419526 Purity: 98%

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Product Citations

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Krueger, Nadine ; Kronenberger, Thales ; Xie, Hang ; Rocha, Cheila ; Poehlmann, Stefan ; Su, Haixia , et al.

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chem. phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 Mpro. Several compounds were discovered to inhibit Mpro at low micromolar concentrations It was possible to crystallize robinetin together with SARS-CoV-2 Mpro, and the X-ray structure revealed covalent interaction with the protease's catalytic Cys145 site. Selected potent mols. also exhibited antiviral properties without cytotoxicity. Some of these powerful inhibitors might be utilized as lead compounds for future COVID-19 research.

Keywords: COVID-19 ; antivirals ; coronavirus ; covalent drugs ; dynamic light scattering ; inhibitors ; main protease ; natural products

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Product Details of Resveratrol

CAS No. :501-36-0
Formula : C14H12O3
M.W : 228.24
SMILES Code : OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1
Synonyms :
trans-Resveratrol; SRT501; Vineatrol 20M
MDL No. :MFCD00133799
InChI Key :LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Pubchem ID :445154

Safety of Resveratrol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of Resveratrol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 501-36-0 ]
 

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